Computational Biology Cover Letter

I submit this application to express my sincere interest in the computational biology position.

Previously, I was responsible for technical expertise in the areas of algorithm development, bioinformatics, data integration & management, visualization, analysis and presentation.

I reviewed the requirements of the job opening and I believe my candidacy is an excellent fit for this position. Some of the key requirements that I have extensive experience with include:

• Experienced with Molecular Dynamics simulations, virtual screening, docking, and pharmacophore analysis
• Experience with construct design, expression, purification of crystallization grade proteins for x-ray crystallography (proteins, protein-ligand and protein-protein complexes)
• Experience with all aspects of protein crystallography – crystallization, crystallization optimization, data collection (in-house/synchrotron), structure determination and refinement, structure analysis
• Provide data analysis and Computational Biology support for the Oncology therapeutic area, working in close collaboration with scientists in Translational Research, Discovery, Clinical Development, and Discovery Sciences to analyze, integrate, and interpret high dimensional data from a variety of platforms including next-generation sequencing, gene expression microarrays, SNP, RBM, and IHC
• Build, analyze, and interpret biological networks from disparate data sources
• Perform real-time bioinformatics and statistical analysis, visualization, and data interpretation for Oncology Disease Area Strongholds (DAS) using statistical and machine learning methods to identify prognostic and predictive biomarker signatures from high dimensional biological data
• Employ strategies integrating data from external
• Evaluate and develop novel algorithms and approaches for data analysis

I submit this application to express my sincere interest in the computational biology position.

In my previous role, I was responsible for modeling and computational expertise, and advance drug discovery projects across our four major therapeutic areas: Oncology, Gastrointestinal, Rare Disease and Neurosciences.

Please consider my qualifications and experience:

• Strong record of developing and publishing computational analyses with a focus on human disease
• Successful track record of leading teams or groups in computational efforts
• Excellent leadership capabilities with demonstrated skill in building, guiding and motivating effective teams and fostering productive research collaborations
• A Bachelors in computer science, computer engineering, software engineering, or related discipline (or significant industry experience)
• Experience with multiple programming languages, including proficiency in C++ or Java
• Scientific curiosity to integrate disciplines of technology, research and healthcare
• Relevant experience/knowledge of pharmacology, mathematics, pharmaceutical/biotechnology sciences and user-interface design and web development is preferred
• Interact with all teams within the research group

In response to your job posting for computational biology, I am including this letter and my resume for your review.

Previously, I was responsible for expert IT consultancy and operational support to an international group of scientists in the global Computational Biology / Bioinformatics groups within the departments Research and Translational Medicine.

Please consider my experience and qualifications for this position:

• Analyze complex datasets to support Oncology Discovery, Translational Research, and Experimental Medicine and communicate results to bench scientists, clinicians, and management in an appropriate biological context
• Prior work experience in a computational biology, bioinformatics or related setting
• Working experience in Unix/Linux environment
• Proficiency with classification and machine learning methods
• Statistical analysis experience with working knowledge of regression analysis, multivariate data analysis, and linear/nonlinear mixed effects modeling
• Experience with BioConductor
• Experience in a variety of programming languages, and strong programming principles (e.g., MATLAB, R, C/C++, Mathematica), and excellent working knowledge of Linux and Windows environments
• Knowledge of scientific computing principles, and IEEE standards

I would like to submit my application for the computational biology opening. Please accept this letter and the attached resume.

Previously, I was responsible for high-quality statistical, computational and biomarker consultation and services to all Teams from discovery through POC to loss of exclusivity.

Please consider my experience and qualifications for this position:

• Data science and computational experience
• Proficiency with coding in R (or other similar languages)
• Significant experience working in a scientific or medical research setting
• Knowledge of molecular biology and particularly transcriptomics
• Interest and experience in machine learning (unsupervised and supervised methods)
• Has a solid background in basic cellular and molecular biology with an understanding of a range of disease areas including gastrointestinal diseases, immunology, inflammation and neurobiology
• Extensive experience with large scale scientific software projects and open source software
• Well developed research plans with a robust scientific track record to include software and/or algorithm development that is aligned with scientific objectives and consistent with current best practices

Please consider me for the computational biology opportunity. I am including my resume that lists my qualifications and experience.

In my previous role, I was responsible for expert IT support in a highly interdependent environment, focusing on AWS infrastructure, platforms and systems for global Computational Biology and Translational Sciences, and as part of BI Dataland.

I reviewed the requirements of the job opening and I believe my candidacy is an excellent fit for this position. Some of the key requirements that I have extensive experience with include:

• Collaborate with cross-functional teams and departments within the organization
• Prior experience with NGS library preparation and in-depth knowledge of advanced molecular biology and genetic engineering techniques
• Extensive wet-lab experience is highly preferable
• Mammalian tissue culture and FACS
• Fluorescence and confocal microscopy
• Experience in microtiter plate assays
• Scientific figures management such as Adobe Illustrator, Inkscape
• PhD in computational biology, computational science, statistics, or mathematics, engineering, genomics/genetics or related fields